Effects of diet and physical activitiy on body weight fluctuation during COVID-19 pandemic in Chinese adults

In 2020, the new virus "COVID-19" is a global epidemic. China has adopted a series of measures such as traffic restrictions, self-isolation at home, and legal isolation of close contacts to curb the development of the epidemic." Eat a healthy diet. However, there is no report on whether the epidemic has affected the diet and health of Chinese residents. A year of research has shown that young overweight and obese people have a higher risk of severe and critical illness after being infected with COVID-19. The life behavior changes caused by home isolation may Therefore, understanding the dietary behavior and life behavior during the epidemic is of great significance to ensure the dietary nutrition and health of Chinese residents and prevent diseases during the special period.

Conformational dynamics of SARS-CoV-2 trimeric spike glycoprotein in complex with receptor ACE2 revealed by cryo-EM (preprint)

The recent outbreaks of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its rapid international spread pose a global health emergency. The trimeric spike (S) glycoprotein interacts with its receptor human ACE2 to mediate viral entry into host-cells. Here we present cryo-EM structures of an uncharacterized tightly closed SARS-CoV-2 S-trimer and the ACE2-bound-S-trimer at 2.7-Å and 3.8-Å-resolution, respectively. The tightly closed S-trimer with inactivated fusion peptide may represent the ground prefusion state. ACE2 binding to the up receptor-binding domain (RBD) within S-trimer triggers continuous swing-motions of ACE2-RBD, resulting in conformational dynamics of S1 subunits. Noteworthy, SARS-CoV-2 S-trimer appears much more sensitive to ACE2-receptor than SARS-CoV S-trimer in terms of receptor-triggered transformation from the closed prefusion state to the fusion-prone open state, potentially contributing to the superior infectivity of SARS-CoV-2. We defined the RBD T470-T478 loop and residue Y505 as viral determinants for specific recognition of SARS-CoV-2 RBD by ACE2, and provided structural basis of the spike D614G-mutation induced enhanced infectivity. Our findings offer a thorough picture on the mechanism of ACE2-induced conformational transitions of S-trimer from ground prefusion state towards postfusion state, thereby providing important information for development of vaccines and therapeutics aimed to block receptor binding.Competing Interest StatementThe authors have declared no competing interest.View Full Text